Studies suggest that up to 50% of periodontitis cases can be attributed to genetic influences. As such, people can be susceptible to periodontitis inherited from one’s parents, and the condition can run in families. This destructive reaction to plaque accumulation is also influenced by the body’s immune response. Anything which suppresses your immune response has the potential to accelerate periodontal destruction. Smoking suppresses the immune response, and numerous studies show far more gum disease destruction in smokers, similarly diabetes will exaggerate the destructive response to plaque. Other influences of periodontal diseases include; puberty, pregnancy, stress and some medications.